Dog DNA summary

Submitted by kdorfman on Wed, 08/02/2023 - 14:47

Genes

letter gene full name traits
E MC1R melanocortin 1 receptor eumelanin (requires signal molecule from agouti or defb) vs. pheomelanin
ee produces a non-functioning MC1R
K defb103 defensin beta 103 (= CBD103 beta-defensin 103) dominant black has a glycine deletion
KB makes a signal that binds tightly to MC1R, preventing agouti expression
B TyRP1 tyrosinase related protein 1 black (B_) vs brown (bb)
A ASIP Agouti Signaling Protein ASIP promotes pheomelanin (aa: no signal, A_ signal with varying on-off patterns)

MC1R Alleles

letter gene full name traits
E
ee

Agouti Alleles

letter gene full name traits
Ay
Aw
aa

NOTE: If you have the nucleotide sequence for an individual and the reference amino acid sequence, to compare them:
Blastx
Query: nucleotide sequence
Subject: reference amino acid sequence