IWP-2
IWP-2 kdorfman Fri, 03/25/2022 - 16:47Selleck Chemical S7085 (Fisher NC0736836)
IWP-2 is an inhibitor of Wnt processing and secretion with IC50 of 27 nM in a cell-free assay, selective blockage of Porcn-mediated Wnt palmitoylation, does not affect Wnt/β-catenin in general and displays no effect against Wnt-stimulated cellular responses. IWP-2 specifically inhibits CK1δ.
Selective inhibitor of Porcn-mediated Wnt secretion.
IWP-2 is useful in both regenerative medicine and anticancer efforts. IWP-2 inactivates Porcn, a membrane-bound O-acyltransferase (MBOAT), and selectively inhibits palmitoylation of Wnt. IWP-2 blocks Wnt-dependent phosphorylation of Lrp6 receptor and Dvl2, and β-catenin accumulation.
Soluble in DMF at 12.5 mg/mL (26.79 mM) Insoluble in water and DMSO
| Concentration | 1 mg/ | 5 mg/ | 10 mg/ |
|---|---|---|---|
| 1 mM | 2.1432 mL | 10.7158 mL | 21.4316 mL |
| 5 mM | 0.4286 mL | 2.1432 mL | 4.2863 mL |
| 10 mM | 0.2143 mL | 1.716 mL | 2.1432 mL |
| 50 mM | - | - | - |