Haloperidol

TCI H0912

C21H23CIFNO2

MW 375.87

Solubility:¹

• 0.1 M HCl: 3 mg/mL
• DMSO: soluble
• H2O: insoluble
• ethanol: soluble (only in theory - in practice, not so much)

Make 10 mL 10mM stock solution: 0.376g in 10 mL DMSO. Vortex to mix

Haloperidol has been used:

• in ethanol to serves as an inhibitor of Erg2p
• to address the mechanism of haloperidol in ferroptosis using hepatocellular carcinoma cells: Hep G2 and Huh-7 cell lines
• in receptor internalization assay
• as an antipsychotic drug in Dulbecco′s Modified Eagle medium

Biochem/physiol Actions:

Haloperidol is a butyrophenone antipsychotic. It is also classified as a neuroleptic (powerful tranquilizer). Haloperidol acts as a D2, D3, and D4 dopamine receptor antagonist and thus causes Parkinson′s disorder. It also has a negative effect on the central nervous system.