Importazole is an inhibitor of importin-β transport receptors.
During interphase, the transport receptor importin-β carries cargoes into the nucleus, where RanGTP releases them. Importazole somehow disrupts the importin/RAN interaction. Importazole is selective among other transporters. Compounds are imported into, but not out of, cells.
A cell-permeable diaminoquinazoline compound that selectively blocks importin-β-mediated nuclear import of NLS bearing cargos in a reversible manner.
Soluble in DMSO (25 mg/ml; clear, colorless solution)
5 mg/mL ailquots in freezer