Submitted by kdorfman on Wed, 04/25/2018 - 21:03

Potassium Ionophore, MW: 1111.32

Sigma V0627

Insoluble in water

stock is 10 mg/mL in DMSO

  • cyclododecadepsi-peptide ionophore antibiotic.
  • potassium ionophore that transports K+ across biological and artificial lipid membranes.
  • can induce K conductivity in cell membranes
  • uncouples oxidative phosphorylation,
  • induces apoptosis in murine thymocytes, and in pre-B cell.
  • inhibits NGF-induced neuronal differentiation
  • antagonizes ET-induced vasoconstriction.
  • Useful in studies of K transport in mitochondria.