GSA 10

Submitted by kdorfman on Thu, 01/28/2021 - 18:39

Smo (Smoothened) receptor* agonist

Tocris 4918 10 mg

MW = 459.94

Make a 5 mM stock solution in 4.34 mL DMSO (heat to 50C to dissolve)

*Non-classical G-protein-coupled receptors that belong to the Frizzled family. Smoothened receptors lack the ability to directly interact with their endogenous ligand, Hedgehog (Hh). In the resting state, Smo receptors are bound to patched (Ptc).

Does not recognize the classic cyclopamine (Cat. No. 1623) binding site. Does not promote Smo translocation to the primary cilium; is strongly potentiated by forskolin and cholera toxin. Displays anti-adipogenic effects in vitro, mediated by a non-canonical Hedgehog signaling pathway. Promotes differentiation of multipotent mesenchymal progenitor cells into osteoblasts.