Submitted by kdorfman on Fri, 03/25/2022 - 16:47

Selleck Chemical S7085 (Fisher NC0736836)

IWP-2 is an inhibitor of Wnt processing and secretion with IC50 of 27 nM in a cell-free assay, selective blockage of Porcn-mediated Wnt palmitoylation, does not affect Wnt/β-catenin in general and displays no effect against Wnt-stimulated cellular responses. IWP-2 specifically inhibits CK1δ.

Selective inhibitor of Porcn-mediated Wnt secretion.

IWP-2 is useful in both regenerative medicine and anticancer efforts. IWP-2 inactivates Porcn, a membrane-bound O-acyltransferase (MBOAT), and selectively inhibits palmitoylation of Wnt. IWP-2 blocks Wnt-dependent phosphorylation of Lrp6 receptor and Dvl2, and β-catenin accumulation.

Soluble in DMF at 12.5 mg/mL (26.79 mM) Insoluble in water and DMSO

Concentration 1 mg/ 5 mg/ 10 mg/
1 mM 2.1432 mL 10.7158 mL 21.4316 mL
5 mM 0.4286 mL 2.1432 mL 4.2863 mL
10 mM 0.2143 mL 1.716 mL 2.1432 mL
50 mM - - -