Selleck Chemical S7085 (Fisher NC0736836)
IWP-2 is an inhibitor of Wnt processing and secretion with IC50 of 27 nM in a cell-free assay, selective blockage of Porcn-mediated Wnt palmitoylation, does not affect Wnt/β-catenin in general and displays no effect against Wnt-stimulated cellular responses. IWP-2 specifically inhibits CK1δ.
Selective inhibitor of Porcn-mediated Wnt secretion.
IWP-2 is useful in both regenerative medicine and anticancer efforts. IWP-2 inactivates Porcn, a membrane-bound O-acyltransferase (MBOAT), and selectively inhibits palmitoylation of Wnt. IWP-2 blocks Wnt-dependent phosphorylation of Lrp6 receptor and Dvl2, and β-catenin accumulation.
Soluble in DMF at 12.5 mg/mL (26.79 mM) Insoluble in water and DMSO
|Concentration||1 mg/||5 mg/||10 mg/|
|1 mM||2.1432 mL||10.7158 mL||21.4316 mL|
|5 mM||0.4286 mL||2.1432 mL||4.2863 mL|
|10 mM||0.2143 mL||1.716 mL||2.1432 mL|