PLK4 (Polo-like kinase) inhibitor
Plk4 has been identified as a master regulator of centriole replication, and its aberrant expression is closely associated with cancer development
PLK4 functions downstream of ROCK2 to drive centrosome amplification in arrested cells. PLK4 overexpression induces centrosome amplification and chromosome instability and causes the suppression of primary cilia formation.
use 125 nM for HeLa (2.5 uL stock in 2 mL medium)
use 300 nM for LLCPk-1 (6 uL stock in 2 mL medium)